In vitro human T cell responses to diphencyprone.

نویسندگان

  • Peter S Friedmann
  • Ciara Haddadeen
  • Chester Lai
  • Eugene Healy
چکیده

Conflicts of interest: The authors declare no conflict of interest. Funding: This work was supported by internal departmental research funds. C. Lai is a Wellcome Trust Research Training Fellow. viral warts and alopecia areata (1–4). It is also used as an experimental tool for investigatation of human immune responses; the contact allergic reactions elicited by DPCP patch tests can be quantified objectively, and the effects of stress, such as intense physical exertion (5), altitude (6), or coexisting human immunodeficiency virus infection (7), can be determined. In order to address possible mechanisms underlying altered immune responses, it is essential to have in vitro systems that allow analysis of the cellular elements involved in the response, such as effector/memory T cells and regulatory T cells. So far,

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Cytotoxic T-Cell Markers and Cytokines in Human Papillomavirus 16

Background and Aim: Cervical cancer is the fourth main cause of mortality among women, and annually about half a million new cases are detected in developed countries. Based on oncological studies, human papillomavirus (HPV) is classified into two categories: high-risk type and low-risk type, and most cases are related to the high-risk type of human papillomavirus. HPV 16 and 18 are among the m...

متن کامل

O-31: Mifepristone Acts as Progesterone Antagonistof Non-Genomic Responses but InhibitsPhytohemagglutinin Induced Proliferationin Human T Cells

Background: Progesterone is an endogenous immunomodulator that suppresses T cell activation during pregnancy. The stimulation of membrane progesterone receptors (mPRs) would seem to be the cause of rapid non-genomic responses in human peripheral T cells, such as an elevation of intracellular calcium ([Ca2+] i) and decreased intracellular pH (pHi). Mifepristoneimmune cells compared with progeste...

متن کامل

Expression Pattern of Interferon-γ in Human Leukemic T Cell Lines Following Treatment with Phytoheamagglutinin, phorbol myristate acetate and Lipopolysaccharide

Background: As a T helper type 1 (Th1) derived cytokine, Interferon gamma (IFN-γ) is an important regulator of inflammatory immune responses. Furthermore, IFN-γ plays an essential role in defense against tumors and intracellular pathogens. This study was designed to assess the pattern of IFN-γ production in human leukemic (Jurkat and Molt-4) T cell lines in vitro. Methods: Ju...

متن کامل

بررسی اثر تماس مستقیم سلولهایT بکر با سلولهای فیبروبلاست تحریک شده با BCG بر القای سلولهایT تنظیمی

Background: Lymph node stromal fibroblasts are interconnected with TCD4+ cells and affect their phenotype and function. Understanding the nature of these interactions under unusual conditions like infections will help to their application in control and regulation of immune responses. Materials and methods: Lymph node fibroblasts were affected in BCG primed immune environment by both in-...

متن کامل

An in vitro study on anti-sickling activity of Terminalia arjuna and Terminalia bellirica

Background & Aim:Combretaceae family is   known for efficacy in the management of sickle cell disorder (SCD). Based on   the earlier reports of anti-sickling property of Terminalia genus the study investigates in vitro antisickling properties of Terminalia arjuna and Terminalia   bellirica. Experimental: Anti-sickling  ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Contact dermatitis

دوره 76 4  شماره 

صفحات  -

تاریخ انتشار 2017